No one else was injured in the crash this morning.
At around 11.40am, a grey Mitsubishi Outlander collided with a wall on Albion Street.
The driver, a man in his sixties, sadly died at the scene.
Police say his next of kin have been informed and a specially trained officer is supporting them.
Investigating officer PC Harry Welch, of the Joint Operations Road Policing Unit, based at Bicester, said: “Sadly a man has died following this collision and our thoughts remain with his family at this time.
“As part of our investigation, I would ask that anyone who witnessed the grey Mitsubishi Outlander driving in the area before or at the time of the collision to please come forward.
“Also I would ask anyone in the area who has CCTV or a video doorbell, or anyone in the area with a dash-cam, to please check their footage and get in touch if it shows anything that could assist our enquiries.
“Anyone with information can contact police by calling 101 or making a report online, quoting reference number 43220283320.”
Thames Water to introduce hosepipe ban
Environmental impact of 57,000 processed foods revealed in Oxford Uni study
Oxford students want domestic violence taught in schools
Seven people injured in Oxfordshire crash
On Air