Police have arrested a man on suspicion of causing death by dangerous driving.
A white van and a lorry collided on the A420 between Buckland and Pusey at around 3am this morning.
The driver of the van, who's in his sixties, sadly died at the scene.
His next of kin have been told and are being supported by specially trained officers.
A 39-year-old man from Surrey is being questioned by police on suspicion of causing death by dangerous driving.
Investigating officer, Detective Sergeant Anthony Jenkins, of the Serious Collision Investigation Unit, said: "We are appealing for anyone who may have witnessed this incident to please come forward.
"I would also ask any motorists who were in the local area around the time to check any dash-cam footage in case it may have captured something that could assist with the investigation.
"Anyone with information can contact us by calling 101, or making a report online, quoting reference 43200216846."